The genetics of adverse drug reactions

Image of drug caplets

Side effects to some drugs may be determined by our genes.

Recent evidence suggests that side effects to some drugs may be determined by our genes (the basic building blocks of life).  This purpose of this study was to identify the genes which determine kidney damage caused by 5-aminosalicylate drugs. It is hoped that we might then be able to develop a test to predict which patients will develop these serious side effect before patients are treated.

This study built on the highly successful research of the UK and international IBD genetics consortia in identifying more than 90 genes for ulcerative colitis and Crohn’s disease. The study was led by UK Gastroenterologists and was supported by the International serious adverse events consortium and the National Institute for health service research.

We recruited 212 patients with ulcerative colitis or Crohn’s disease, aged over 16, who have developed kidney damage following the use of any of these 5-aminosalicylate drugs.

We are in the process of publishing the results for this study.