Predicting 5ASA induced renal failure

Image of drug caplets

Side effects to some drugs may be determined by our genes.

Recent evidence suggests that side effects to some drugs may be determined by our genes (the basic building blocks of life).  This purpose of this study is to identify the genes which determine kidney damage caused by 5-aminosalicylate drugs. It is hoped that we might then be able to develop a test to predict which patients will develop these serious side effect before patients are treated.

This study builds on the highly successful research of the UK and international IBD genetics consortia in identifying more than 90 genes for ulcerative colitis and Crohn’s disease. The study is led by UK Gastroenterologists and is supported by the International serious adverse events consortium and the National Institute for health service research.

This study has now closed.