Volunteers wanted for genetic study of rare drug side effects
We are looking for volunteers with ulcerative colitis or Crohn’s disease who have had any of the following conditions and complications:
1. Have developed either bone marrow suppression, pancreatitis, liver injury or hypersensitivity following the use of mercaptopurine (Puri-Nethol) or azathioprine (Imuran).
2. Have developed nerve damaged following treatment with a class of drugs called anti-TNF medications, which include Infliximab (Remicade) and Adalimumab (Humira).
It is not known why some people develop these serious side effects. Recent evidence suggests that side effects to some drugs may be determined by our genes (the basic building blocks of life). The purpose of this study is to identify the genes that may lead to these side effects. It is hoped that we might be able to develop a test to predict those who will have side effects with these drugs.
Participants will be asked to complete a short questionnaire, donate a blood sample for DNA analyses at their local hospital and give permission to allow review of their medical notes.
This study builds on the highly successful research of the UK and international IBD genetics consortia in identifying more than 90 genes for ulcerative colitis and Crohn’s disease. The study is led by UK Gastroenterologists and is supported by the International serious adverse events consortium and the National Institute for Health service Research.
People interested in volunteering for the study should contact Claire Bewshea on 01392 406928 or by email at firstname.lastname@example.org