The main aim of this study is to identify clinically useful genetic markers that predict 5-ASA nephrotoxicity, so that these drugs can be avoided, or renal monitoring intensified, in genetically high risk patients. A simple, cheap, diagnostic test will be developed using these data which can be rapidly adopted into medium and large sized hospitals.

The secondary objectives are:

(a)   to understand the mechanisms underlying 5-ASA induced nephrotoxicity

(b)   through a knowledge of the mechanisms, to learn about particular functional chemical groups which predispose to toxicity, and thereby facilitate more rational drug design.

(c)    to establish a network of interested gastroenterologists for further pharmacogenetic research projects.