Thiopurine Hypersensitivity Reaction

Thiopurine Hypersensitivity Reaction is a new study added to the Predicting Drug Side Effects in Gastroenterology (PRED4) at the beginning of 2015.

The inclusion criteria are as follows:

  • Aged 6 years or over
  • History of Inflammatory Bowel Disease
  • History of thiopurine exposure in the previous 7 days before the onset of adverse event
  • Flu like symptoms  severe enough to lead to drug withdrawal even if temporary (symptoms should include one of the following: fever, muscle ache, joint pain)
  • Onset of symptoms within 4 weeks of starting thiopurine
  • Symptoms resolved within 14 days of drug withdrawal

Exclusion Criteria

  • Patient tolerated re-challenge with the same thiopurine regardless of dose
  • Drug withdrawn due to nausea and/or diarrhoea without any other symptoms
  • Objective evidence of Infection

IBD THR CRF v4 July 15

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