Thiopurine induced Liver injury was added to the Predicting Drug Side Effects in Gastroenterology (PRED4) at the beginning of 2014.
The inclusion criteria are as follows:
• History of inflammatory bowel disease
• Normal ALT and bilirubin at baseline
• No pre-existing liver disease
• Elevation of ALT and/or bilirubin to >= 4 times upper limit of normal
• History of thiopurine exposure in the previous 30 days prior to this abnormal blood test
• Medical opinion implicating thiopurine in development of hepatotoxicity leads to dose reduction or drug withdrawal (even if temporary.
The CRF is available below.
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